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The Toxicity Of Dichlorvos
Aug 08, 2018

The toxicity of


Dichlorvos is a broad-spectrum insecticide and acaricidal agent. It has the functions of curettage, stomach poison and fumigation. The killing effect is better than that of trichlorfon.



Moderate toxic insecticide. The crude drugs are flammable and the cream is flammable. Oral LD50:80mg/kg in the primary male rats; Female rats transoral LD50:56mg/kg; Male rat percutaneous LD50:107mg/kg; Female rat percutaneous LD50:75mg/kg. The inactive dose of male rats was 1000ppm. Gill fish TLm (24 hours) 1mg/L, big molas 2 hours lc50:1 PPM. 80% dichlorvos can be inhaled by mouth, skin or respiratory tract. Oral poisoning victims have a short incubation period, rapid onset, serious illness, often have coma, can die within a few minutes. The symptoms of digestive tract stimulation are obvious in oral patients.



Toxicity: moderate toxicity.



Acute toxicity: LD5050 ~ 92mg/kg (mice oral); 50 ~ 110mg/kg (rat via mouth)



Subacute and chronic toxicity: chronic poisoning in rabbits with oral dose of more than 0.2mg (kg· d) over 24 weeks, over 1mg (kg· d), severe lesions in animal liver clouds, and continuous decrease in ChE.



Mutagenicity: microorganism mutagenicity: salmonella typhus 330.



DNA inhibition: a human lymphocyte 100 is a function of L.



Sperm morphological changes: 35mg/kg in the abdomen of mice, 5 days.



Reproductive toxicity: the lowest dose of oral toxicity (TDL0) in rats was 39200 francs g/kg (14 ~ 21 days of gestation), resulting in biochemical and metabolic changes in newborn rats.



Carcinogenicity: the lowest dose of oral poisoning in rats (TDL0) : 4120mg/kg, 2 years (continuously), carcinogenic, lung tumor, gastrointestinal tumor. The minimum percutaneous toxic dose of mice (TDL0) : 20600mg/kg, 2 years (continuously), carcinogenic, gastrointestinal tumors.



The product is also easy to be absorbed through skin penetration. The LD50 absorbed through skin penetration is 75 ~ 107mg/kg.



The safe dose of no effect on human is 0.033mg per kg per day.



Special toxicity: gene mutation, mouse lymphocyte negative.



Metabolism and degradation: in the environment, the saturated aqueous solution of dichlorvos is hydrolyzed at room temperature at a rate of about 3% per day to form dimethylphosphoric acid and dichloroacetaldehyde, which is hydrolyzed faster under alkaline conditions.



Residues and accumulate: dichlorvos in the environment is quite easy to decompose, at 30 ℃, 18 days 50% dichlorvos hydrolysis.



Migration transformation: due to the high vapor pressure of dichlorvos, it is easy to enter the atmosphere. The migration and transformation of dichlorvos is mainly through air and water.



Dangerous characteristics: in the case of open fire, high heat combustible. Decomposition by heat releases toxic gases of phosphorus oxide and chloride.



Combustion (decomposition) products: carbon monoxide, carbon dioxide, hydrogen chloride, phosphorus oxide.