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The Most Common Adverse Reactions Of Daptomycin
Jun 29, 2018

Deal with resistance to new antibiotics the pressing needs of the patient, at the end of 2003, the United States food and drug administration (FDA) following a quick trial program approval for injection of tora toxin (Daptomycin) (trade name cubicin) used to treat some gram positive strains of the sensitive concurrency skin and skin structure infections, such as abscess, infection of incision and skin ulcers. It can also be used in right infective endocarditis caused by staphylococcus aureus. Bacteremia caused by staphylococcus aureus associated with RIE or complicated skin and soft tissue infections. Of different mechanism of the drug, and other antibiotics, it by disrupting the cell membrane transport of amino acids, which hinder the biosynthesis of bacterial cell wall peptidoglycan, change the nature of the cytoplasmic membrane; In addition, it can also sterilize bacteria by destroying their cell membranes and allowing their contents to leak out. Therefore, it may be difficult for bacteria to develop resistance to datoramycin.


The most common adverse reactions include constipation, localized reactions at the injection site, nausea, headache, diarrhoea and vomiting. The gastrointestinal response is due to the effect of drugs on intestinal flora. In addition, after receiving the multi-dose intravenous administration of the medicine, healthy volunteers showed increased transient myasthenia, muscle pain and C P K, and the adverse reactions disappeared or partially reversed after discontinuing the medication. Datoramycin was not associated with neurotoxicity at any dose.