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Pharmacological Action And Clinical Application
Jul 02, 2018

For drug mechanism is different from other antibiotics, it by disrupting the cell membrane transport of amino acids, which hinder the biosynthesis of bacterial cell wall peptidoglycan, change the nature of the cytoplasmic membrane; In addition, it can also sterilize bacteria by destroying their cell membranes and allowing their contents to leak out. Therefore, it may be difficult for bacteria to develop resistance to datoramycin. It is clinically used to treat complicated skin and skin structure infections caused by some gram-positive sensitive strains. Treating gram-positive bacteria causes complex skin and skin structure infections, such as abscesses, incision infections and skin ulcers, including staphylococcus, which is sensitive to methoxicillin (resistant to drugs). Used for right infective endocarditis caused by staphylococcus aureus; Bacteremia caused by staphylococcus aureus associated with RIE or complicated skin and soft tissue infections.