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Daptomycin Pharmacokinetics
Jan 07, 2019

Distribution: Kebisin can reversibly bind to human plasma proteins (mainly serum albumin) and is not associated with plasma concentrations. The total average protein binding rate ranges from 90 to 93%.

In healthy adult subjects, the steady state volume of distribution (Vss) of Ketzin is about 0.10 L/kg and is not related to the dose used.

Metabolism: In vitro studies of human hepatocytes showed that ketone had no inhibition or induction of the activity of the following human cytochrome P450 isozymes: 1A2, 2A6, 2C9, 2C19, 2D6, 2E1 and 3A4. In in vitro studies, ketone is not metabolized by human liver microsomes. Therefore, Ke Bixin is unlikely to inhibit or induce drug metabolism in the P450 system.

Excretion: Ke Bixin is mainly excreted by the kidneys. In a mass balance study, 5 healthy subjects were given radiolabeled ketidine. According to the total radioactivity, about 78% of the administered dose was recovered from the urine (about 52% of the administered dose was recovered according to the microbial activity concentration); and 5.7% of the administered dose was recovered from the feces based on the total radioactivity (collection Up to 9 days).

Since renal excretion is the main route of elimination of the drug, it is necessary to adjust the dose for patients with severe renal insufficiency (CLCR < 30 mL / min) (see dosage and usage).


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