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Rosuvastatin Intermediate R-3

Structure : Description Certificate of Analysis ProductName: (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester (R-2) Cas: 355806-00-7 Batch No.: 140301 MFG Date: Mar. 08 2014 Analysis Date:Mar.08.2014

  • Features & Specification

    PRODUCT   NAME

    (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic   acid tert-butyl ester  (R-2)

    CAS   No.:

    355806-00-7

    Synonyms:

    tert-Butyl rosuvasta;

    Rosuvastatin intermediate R-3;

    Formula:

    C26H36FN3O6S

    Molecular   Weight:

    537.64400

    PSA:

    138.30000

    LogP:

    4.73960

     

    Structure

    image.png                  

     

    Description

    Appearance   & Physical State:

    white   to off-white crystal powder

    Density:

    1.259

    Boiling   Point:

    704.158ºC   at 760 mmHg

    Flash   Point:

    379.661ºC

    Refractive   Index:

    1.564

    HS   Code:

    2935009090

     

    Certificate of Analysis

     

    ProductName: (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-[(methanesulfonyl)methylamino]pyrimidin-5-yl]-3,5-dihydroxyhept-6-enoic acid tert-butyl ester  (R-2)

    Cas:       355806-00-7

    Batch No.:     140301

    MFG Date:  Mar. 08 2014

    Analysis Date:Mar.08.2014

     

    Inspect   Item

    Quantity   Standard

    Inspection   Result

    Description

    White   wo off-white powder

    White   powder

    Specific   rotation

    +21.0°- +26.0°

    +23.31°

    Loss   on drying

    NMT   1.00%

    0.14%

    Single   impurity

    NMT   0.50%

    0.13%

    Total   impurity

    NMT   1.00%

    0.52%

    Purtiy

    NLT   99.0%

    99.48%

    Conclusion  

    In   accordance with enterprise standard


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