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Rapamycin

Structure : Description : A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to...

  • Features & Specification

    PRODUCT NAME

    Rapamycin

    CAS No.:

    53123-88-9

    Synonyms

    Sirolimus

    Formula

    C51H79NO13

    Molecular Weight

    914.17200

    PSA:

    195.43000

    LogP:

    6.11850

    Structure: 

    图片29.png

    Description
    A triene macrolide antibiotic isolated from Streptomyces hygroscopicus. Name derived from the native word for Easter Island, Rapa’Nui. Used as an immunosuppressant; antirestenotic. Sirolimus (INN/USAN), also known as rapamycin, is an immunosuppressant drug used to prevent rejection in organ transplantation; it is especially useful in kidney transplants.

    Appearance & Physical State:

    yellow solid

    Density:

    1.182 g/cm3

    Melting Point:

    183-185ºC

    Boiling Point:

    973.017ºC at 760 mmHg

    Flash Point:

    542.261ºC

    Refractive Index:

    1.55

    Stability:

    Stable if stored as directed.

    Storage Condition:

    -20ºC

    Safety Statements:

    S22-S24/25

    HS Code:

    2942000000

    Risk Statements:

    R36/38

    Hazard Codes:

    Xi

    certificate of analysis

    ProductName: Rapamycin
     Cas:   53123-88-9
     Batch No.: 130301
     MFG Date:  Mar.2.2013
     Analysis Date: Mar.2.2013

    Inspect Item

    Quantity Standard

    Inspection Result

    Appearance

    White or almost white crystalline powder

    Conforms

    Identification

    Positive

    Conform

    Total related substances

    5.0% Max

    2.4%

    Demethyl rapamycin

    3.0% Max

    0.8%

    Isomer

    6.0% Max

    2.2%

    Water content

    0.5% Max

    0.2%

    Residue on ignition

    0.2% Max

    0.1%

    Specific rotation

    -147°to -157°

    -153°

    Heavy metals

    0.002% Max

    Conform

    Assay (dried basis)

    98% Min

    99.1%

    Conclusion

    In accordance with enterprise standard

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