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(3R,5S,6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl- N-methylsulfonyl Amino)pyrinidine-5-yl]-3,5-dihydrosy-6-heptane Acid,Methyl Ester

Rosuvastatin Methyl Ester is an impurity of Rosuvastatin in the pharmaceutical dosage forms under forced degradation conditions.

  • Features & Specification

    PRODUCT   NAME

    (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-

    N-methylsulfonyl amino)pyrinidine-5-yl]-3,5-dihydrosy-6-heptane   acid,Methyl ester

    CAS   No.:

    147118-40-9

    Synonyms:

    (+)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methanesulfonyl-methyl-amino)-pyrimidin-5-yl)-(3R,5S,6E)-dihydroxy-hept-6-enoic   acid methyl ester;

    methyl   (E,3R,5S)-7-[4-(4-fluorophenyl)-2-[methyl(methylsulfonyl)amino]-6-propan-2-ylpyrimidin-5-yl]-3,5-dihydroxyhept-6-enoate

    Formula:

    C23H30FN3O6S

    Molecular   Weight:

    495.56400

    PSA:

    138.30000

    LogP:

    3.57090

     

    Structure

    image.png                  

     

    Description

    Density:

    1.313g/cm3

    Boiling   Point:

    692.3ºC   at 760 mmHg

    Flash   Point:

    372.5ºC

    Refractive   Index:

    1.575

    Vapor   Pressure:

    4E-20mmHg   at 25°C

    HS   Code:

    2935009090

     

    Certificate of Analysis

     

    ProductName: (3R,5S,6E)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-

    N-methylsulfonyl amino)pyrinidine-5-yl]-3,5-dihydrosy-6-heptane acid,Methyl ester

    Cas:       147118-40-9

    Batch No.:     20140312

    MFG Date:  Mar.12.2014

    Analysis Date:Mar.13.2014

     

    Inspect   Item

    Quantity   Standard

    Inspection   Result

    Appearance

    White   or almostwhite crystalline powder

    Conforms  

    Assay

    ≥98.0%

    98.9%

    Special   optical rotation

    +23.0~26.0°

    + 24.1°

    Water  

    0.5%MAX

    0.4%

    Related   impurities

    Individual   :0.5%MAX

    0.3%

    Total   :2.0%MAX

    1.1%

    Conclusion  

    In   accordance with enterprise standard


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