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(1R,2S,5R)-menthyl-5R-hydroxy-1,3-oxathiolane-2 R-carboxylate (HME)

HME is an important intermediate for the production of LAMIVUDINE. Shitai Biotech is custom-made for customers. The chemical properties of the product are stable.

  • Features & Specification

    PRODUCT   NAME

    (1R,2S,5R)-menthyl-5R-hydroxy-1,3-oxathiolane-2   R-carboxylate

    CAS   No.:

    147126-73-6

    Synonyms

    HME

    5-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-1,3-oxathiolane-2-carboxylic acid   5-methyl-2-(1-methylethyl)cyclohexyl ester

    Formula:

    C18H27N3O4S

    Molecular   Weight:

    381.49000

    PSA:

    121.74000

    LogP:

    2.99880

     

    Structure

    image.png  

     

    Description

    Appearance & Physical State:

    White To Off-White Solid

    Density:

    1.42

    Melting Point:

    99-101ºC

    Boiling Point:

    525ºC at 760 mmHg

    Flash Point:

    271.3ºC

    Refractive Index:

    1.654

    Vapor Pressure:

    4.1E-11mmHg at 25°C

     

    Certificate of Analysis

     

    ProductName: HME

    CAS:147126-73-6

    Batch No.:     110505

    MFG Date:  May.05.2011

    Analysis Date: May.05.2011

     

    Inspect Item

    Quantity Standard

    Inspection Result

    Appearance

    light   yellow or off-white powder.

    Conforms

    Loss   On Drying

    ≤0.50%

    0.29%

    Melting   range

    95.5℃ ~ 102℃

    96.7~99.3℃

    Specific   optical rotation

    (10mg/ml   in methanol at20℃)

    -55.0~-60.0 °

    -58.02°

    Conclusion  

    In   accordance with enterprise standard


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