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ZD-6 CAS No.:147118-39-6 intermediates provide by Hangzhou Shitai Biotech
Apr 24, 2018

5-Oxorosuvastatin methyl ester is an intermediate in the synthesis of Rosuvasatatin (calcium salt: R700500), a 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor that decreases high-sensitivity C-reactive protein (hsCRP) and cholesterol concentrations in the blood.


PRODUCT   NAME

methyl(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6F)-heptenoate

CAS   No.:

147118-39-6

Synonyms:

ZD-6;

Methyl(+)-(3-R)-7-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-Methyl-N-Methanesul   fonylaMino) pyriMidin-5-y;

Formula:

C23H28FN3O6S

Molecular   Weight:

493.54800

PSA:

135.14000

LogP:

3.77910

 

Structure

image.png                  

 

Description

Density:

1.311g/cm3

Boiling   Point:

701.7ºC   at 760 mmHg

Flash   Point:

378.2ºC

Refractive   Index:

1.569

Vapor   Pressure:

1.15E-20mmHg   at 25°C

 

Certificate of Analysis

 

ProductName: methyl(+)-(3R)-7-[4-(4-fluorophenyl)-6-isopropyl-2-(N-methyl-N-methanesulfonylamino)pyrimidin-5-yl]-3-hydroxy-5-oxo-(6F)-heptenoate

Cas:       147118-39-6

Batch No.:     20130922

MFG Date:  Sep.24.2013

Analysis Date:Sep.25.2013

 

Inspect   Item

Quantity   Standard

Inspection   Result

Appearance

Yellow   crystalline powder

Yellow   crystalline powder

Assay  

98.0%   MIN

98.3%

Specific   rotation

7.5   - 9.5º

8.56º

Identification  

Infrared   absorption spectrum should be consistent with the standard spectrum

Associated   with the standard spectrum

Loss   on drying

0.5%MAX

0.2%

Single   impurity

1.0%MAX

0.8%

Total   impurities

2.0%MAX

1.9%

Conclusion  

In   accordance with enterprise standard


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