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t-Butyldimethylsilyl chloride CAS No.:18162-48-6
Mar 14, 2018

PRODUCT   NAME

t-Butyldimethylsilyl chloride

CAS   No.:

18162-48-6

Synonyms

tert-Butyl(chloro)dimethylsilane;

TBDMSCL;

Formula:

C6H15ClSi

Molecular   Weight:

150.72200

PSA:

0.00000

LogP:

3.23040

 

Structure

Description

Appearance & Physical State:

White solid

Density:

0.81

Melting Point:

85-91ºC

Boiling Point:

125ºC

Flash Point:

22ºC

Refractive Index:

n20/D 1.46

Stability:

Stable under normal temperatures and pressures.

Storage Condition:

Store at 5ºC

Vapor Pressure:

12.089mmHg at 25°C

Symbol:

http://or.molbase.net/themes/pic/images/GHS02.png
  GHS02
http://or.molbase.net/themes/pic/images/GHS05.png
  GHS05

Sign:

Danger

hazard declaration:

H228; H314

hazard declaration add:


waring notice:

P210; P280; P305 + P351 + P338; P310

RTECS:

VV2000000

Hazard Class:

4.1

Safety Statements:

S16-S25-S36/37/39-S45

HS Code:

29310095

Packing Group:

III

WGK Germany:

2

RIDADR:

UN 2925 4.1/PG 2

Risk Statements:

R10; R34

Hazard Codes:

C

 

 

certificate of analysis

 

ProductName: t-Butyldimethylsilyl chloride

Cas:        18162-48-6        

Batch No.:     20101229

MFG Date:  Dec.29.2010

Analysis Date:Dec.29.2010

 

Inspect Item

Quantity Standard

Inspection Result

Appearance

White crystal

Conforms

Assay

≥99.0%

99.41%

Identification

The retention times of the t-Butyldimethylsilyl chloride peal in   the sample and standard chromatograms are essentially the same(within ±2.5%)

Conforms

Melting Point

86.0℃ ~90.0℃

87.4℃~88.5℃

t-Butyldimethylsilylchol

Assay

≤0.50%

0.16%

Conclusion

In accordance with enterprise standard

 

QC Manager: 李莉                     Analyst: 王华


18162-48-6 is a fine chemical provided by Hangzhou Shitai Biotech Co., Ltd. At the same time, this product can be used to synthesize prostaglandins, some antibiotics, lipid lowering drugs, lovastatin and simvastatin, and can also be used in pharmaceutical intermediates and organic synthesis, and as hydroxyl protectants in organic synthesis. It can also be used as a hydroxyl protector in organic synthesis, and the derivatization reagents are used for analysis and preparation. Protect the tertiary alcohols. Reaction with the alcohols to form a silicone ether. Determination of the conformation of a cholesterol derivative. The synthesis of prostaglandins, certain antibiotics, lipid-lowering drugs Rolf Steen (Lovastatin) and new vuursteen (Simvastatin) auxiliary materials. The preparation method of the product is to cool the Pentane Solution of two chloro two methyl silane to 0 C and drop the Pentane Solution of tert butyl lithium under nitrogen and agitation. At 0 C, the reaction of 1.5h was heated to 25 C after agitation and the reaction of 48h. Distillation, collecting 125 C (97.5kPa) fraction, static curing, have two tert butyl methyl chlorosilane. The yield is 70%. The content is divided into 95%, 97%, 98%, according to the customer's requirements. 99.5% different specifications. Our company has 7 years of product management history. The products provided to the big enterprises in South Korea have been recognized by the customers.


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