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Crizotinib (trade name Xalkori, Pfizer) is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor, approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US and some other countries, and undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and children.
PRODUCT NAME | 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine | ||
CAS No.: | 877399-52-5 | ||
Synonyms: | |||
Formula: | C21H22Cl2FN5O | Molecular Weight: | 450.33700 |
PSA: | 77.99000 | LogP: | 5.94770 |
Structure:
Description
Density: | 1.475g/cm3 |
Boiling Point: | 599.177ºC at 760 mmHg |
Flash Point: | 316.171ºC |
Refractive Index: | 1.673 |
Symbol: | |
Sign: | Warning |
hazard declaration: | |
hazard declaration add: | |
waring notice: | P273; P280; P305 + P351 + P338 |
HS Code: | 2933990090 |
Certificate of Analysis
ProductName: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)
-1H-pyrazol-4-yl]pyridin-2-amine
Cas: 877399-52-5
Batch No.: 20110325
MFG Date: Mar.25.2011
Analysis Date: Mar.25.2011
Inspect Item | Quantity Standard | Inspection Result |
Appearance | N/A | Pink powder |
HNMR | Comply with the structure | Conforms |
LC-MS | Comply with the structure | Conforms |
Purity | ≧98% | 98.38%(by LC-MS) |
ee | ≧98% | 98.26%(by HPLC) |
Melting point | N/A | N/A |
Conclusion | In accordance with enterprise standard |
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