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(R)-Crizotinib CAS No.:877399-52-5 supplier Hangzhou Shitai Biotech
May 09, 2018

Crizotinib (trade name Xalkori, Pfizer) is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor, approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US and some other countries, and undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and children.

PRODUCT   NAME

3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine

CAS   No.:

877399-52-5

Synonyms:

(R)-Crizotinib;

Xalkori;

Formula:

C21H22Cl2FN5O

Molecular   Weight:

450.33700

PSA:

77.99000

LogP:

5.94770

 

Structure

image.png                         

 

Description

Density:

1.475g/cm3

Boiling   Point:

599.177ºC   at 760 mmHg

Flash   Point:

316.171ºC

Refractive   Index:

1.673

Symbol:


  GHS07

  GHS08

  GHS09

Sign:

Warning

hazard   declaration:

H317; H319; H341; H400

hazard   declaration add:


waring   notice:

P273;   P280; P305 + P351 + P338

HS   Code:

2933990090

 

Certificate of Analysis

 

ProductName: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)

-1H-pyrazol-4-yl]pyridin-2-amine

Cas:        877399-52-5

Batch No.:     20110325

MFG Date:  Mar.25.2011

Analysis Date: Mar.25.2011

 

Inspect   Item

Quantity   Standard

Inspection   Result

Appearance

N/A

Pink   powder

HNMR

Comply   with the structure

Conforms  

LC-MS

Comply   with the structure

Conforms

Purity

≧98%

98.38%(by   LC-MS)  

ee

≧98%

98.26%(by   HPLC)

Melting   point

N/A

N/A

Conclusion  

In   accordance with enterprise standard


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