(R)-Crizotinib CAS No.:877399-52-5 supplier Hangzhou Shitai Biotech - Knowledge

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(R)-Crizotinib CAS No.:877399-52-5 supplier Hangzhou Shitai Biotech

May 09, 2018

Crizotinib (trade name Xalkori, Pfizer) is an anti-cancer drug acting as an ALK (anaplastic lymphoma kinase) and ROS1 (c-ros oncogene 1) inhibitor, approved for treatment of some non-small cell lung carcinoma (NSCLC) in the US and some other countries, and undergoing clinical trials testing its safety and efficacy in anaplastic large cell lymphoma, neuroblastoma, and other advanced solid tumors in both adults and children.

PRODUCT NAME	3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)-1H-pyrazol-4-yl]pyridin-2-amine
CAS No.:	877399-52-5
Synonyms:	(R)-Crizotinib;
	Xalkori;
Formula：	C21H22Cl2FN5O	Molecular Weight：	450.33700
PSA:	77.99000	LogP:	5.94770

Structure：

Description

Density:	1.475g/cm3
Boiling Point:	599.177ºC at 760 mmHg
Flash Point:	316.171ºC
Refractive Index:	1.673
Symbol:	GHS07 GHS08 GHS09
Sign:	Warning
hazard declaration:	H317; H319; H341; H400
hazard declaration add:
waring notice:	P273; P280; P305 + P351 + P338
HS Code:	2933990090

Certificate of Analysis

ProductName: 3-[(1R)-1-(2,6-Dichloro-3-fluorophenyl)ethoxy]-5-[1-(4-piperidinyl)

-1H-pyrazol-4-yl]pyridin-2-amine

Cas: 877399-52-5

Batch No.: 20110325

MFG Date: Mar.25.2011

Analysis Date: Mar.25.2011

Inspect Item	Quantity Standard	Inspection Result
Appearance	N/A	Pink powder
HNMR	Comply with the structure	Conforms
LC-MS	Comply with the structure	Conforms
Purity	≧98%	98.38%(by LC-MS)
ee	≧98%	98.26%(by HPLC)
Melting point	N/A	N/A
Conclusion	In accordance with enterprise standard