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new drug Acalabrutinib CAS No:1420477-60-6 made by Hangzhou Shitai Biotech Co.,Ltd
Feb 07, 2018

PRODUCT NAME

Acalabrutinib

CAS No.:

1420477-60-6

Synonyms

(S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide

ACP196

Formula:

C26H23N7O2

Molecular Weight:

465.50700

PSA:

118.51000

LogP:

3.90470


Acalabrutinib CAS No.:1420477-60-6 as a new drug develeped by Hangzhou Shitai Biotech Co.,LTD .

Our company as the biggest manufacturer have 3 year for Acalabrutinib production. we can provide the intermediates (S)-benzyl 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate CAS:1420478-88-1 and N-(Pyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide CAS No.:1383385-64-5.As a new drug that has just been approved by the market, we have deeply analyzed the structure of the product, impurities, and many other factors. Considering the specific conditions of production, we provide a comprehensive analysis of the intermediate (S)-benzyl 2-(8-amino-1-bromoimidazo[1,5-a]pyrazin-3-yl)pyrrolidine-1-carboxylate CAS:1420478-88-1 and N-(Pyridin-2-yl)-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzamide CAS No.:1383385-64-5. In contrast, the stability of the two intermediates is better than that of the others. We have also made a specific analysis of the components and impurities of the intermediate. The results did not affect the results of the final API. We have reason to believe that in the future, A will be opened in a large scale production market.Hangzhu Shitai Biotech Co., LTD has completed the preparatory work in the early stage, and sincerely invited all the major pharmaceutical companies to seek cooperation, and jointly develop GMP/DMF file preparation and production preparation. Do all the work to open the European and American market.

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