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Daptomycin CAS No.:103060-53-3 supplier Hangzhou Shitai Biotech
May 10, 2018

Daptomycin is a lipopeptide antibiotic used in the treatment of systemic and life-threatening infections caused by Gram-positive organisms. It is a naturally occurring compound found in the soil saprotroph Streptomyces roseosporus. Its distinct mechanism of action makes it useful in treating infections caused by multiple drug-resistant bacteria. It is marketed in the United States under the trade name Cubicin by Cubist Pharmaceuticals.


PRODUCT   NAME

Daptomycin

CAS   No.:

103060-53-3

Synonyms:

CUBICIN DAPTOMYCIN;

N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone;

Formula:

C72H101N17O26

Molecular   Weight:

1620.67000

PSA:

702.02000

LogP:

0.88280

 

Structure

image.png                         

 

Description

Appearance   & Physical State:

White   powder

Density:

1.45   g/cm3

Boiling   Point:

2078.2ºC   at 760 mmHg

Flash   Point:

1210.7ºC

Refractive   Index:

1.638

Vapor   Pressure:

0mmHg   at 25°C

 

Certificate of Analysis

 

ProductName: Daptomycin

Cas:        103060-53-3

Batch No.:     20120201

MFG Date:  Feb.01.2012

Analysis Date: Feb.01.2012

 

Inspect   Item

Quantity   Standard

Inspection   Result

Appearance  

Yellow   or pale yellow amorphous powder

Conforms

Identification  

HPLC,   IR, UV

Conforms

Specific   Rotation

+17°~+25°

+21.6°

PH

4.0~5.0

4.78

Residue   on ignition

≤4.0%

3.27%

Related   Substances(HPLC)

Anhydro-datomycin≤2.5%

0.48%

β-Isomer≤2.0%

0.55%

Lactone   hydrolysis product≤1.0%

0.42%

Any   other impurity≤1.0%

<1.0%

Total   impurities≤4.0%

3.08%

Residual   Organic

Solven

Ethanol≤1.0%

Absent

Isopropanol≤0.5%

Absent

Heavy   Metals

≤20PPM

<20PPM

Water

≤10.0%

2.86%

Assay(on   the anhydrous basis)

≥93.0%

99.3%

Bacterial   Endotoxin

<1.25EU/MG

<0.1EU/MG

Conclusion  

In   accordance with enterprise standard


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