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Azacitidine intermediates of 5-Azacytidine CAS No.:320-67-2 supplier Hangzhou Shitai Biotech Co.,Ltd
Apr 19, 2018

Azacitidine (INN; trade name Vidaza) is a chemical analog of cytidine, a nucleoside in DNA and RNA. Azacitidine and its deoxy derivative, decitabine (also known as 5-aza-2′deoxycytidine), are used in the treatment of myelodysplastic syndrome. Both drugs were first synthesized in Czechoslovakia as potential chemotherapeutic agents for cancer.


PRODUCT   NAME

5-Azacytidine

CAS   No.:

320-67-2

Synonyms:

5-AC;

5 AZC;

Formula:

C8H12N4O5

Molecular   Weight:

244.20500

PSA:

143.72000

LogP:

-2.58680

 

Structure

image.png                  

 

Description

Appearance   & Physical State:

white crystalline powder

Density:

2.08 g/cm3

Melting   Point:

228-230ºC

Boiling   Point:

534.5ºC at 760 mmHg

Flash   Point:

277ºC

Refractive   Index:

1.823

Water   Solubility:

0.5-1.0 g/100 mL at 21 ºC

Stability:

Stable under normal temperatures and pressures.

Storage   Condition:

2-8ºC

Symbol:

image.png
  GHS07
image.png
  GHS08

Sign:

Danger

hazard   declaration:

H302; H350

hazard   declaration add:


waring   notice:

P201; P308 + P313

RTECS:

XZ3017500

Safety   Statements:

S53-S22-S36/37/39-S45

HS   Code:

2934999090

WGK   Germany:

3

Risk   Statements:

R45; R46; R22

Hazard   Codes:

T

 

Certificate of Analysis

 

ProductName: 5-Azacytidine

Cas:        320-67-2

Batch No.:     20110406

MFG Date:  Apr.06.2011

Analysis Date: Apr.06.2011

 

Inspect   Item

Quantity   Standard

Inspection   Result

Appearance

White   or almost white crystalline powder

White   crystalline powder

Assay   (HPLC)

≥98.0%

99.52%

Residue   on ignition

≤0.5%

0.15%

Loss   on drying

<1.0%

0.50%

Heavy   Metals

≤20ppm

Conforms  

Conclusion  

In   accordance with enterprise standard


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