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Anastrozole CAS No.:120511-73-1 supplier Hangzhou Shitai Biotech
Apr 27, 2018


Anastrozole (INN) (marketed under the trade name Arimidex by AstraZeneca) is a non-steroidal aromatase-inhibiting drug approved for treatment of breast cancer after surgery, as well as for metastasis in both pre and post-menopausal women. The severity of breast cancer can be increased by estrogen, as sex hormones cause hyperplasia, and differentiation at estrogen receptor sites. Anastrozole works by inhibiting the synthesis of estrogen. The patent on Arimidex by AstraZeneca expired June 2010.
It is on the World Health Organization's List of Essential Medicines, a list of the most important medications needed in a basic health system.


PRODUCT   NAME

Anastrozole

CAS   No.:

120511-73-1

Synonyms:

Anastrol;

2,2'-(5-((1H-1,2,4-Triazol-1-yl)methyl)-1,3-phenylene)bis(2-methylpropanenitrile);

Formula:

C17H19N5

Molecular   Weight:

293.36600

PSA:

78.29000

LogP:

2.92876

 

Structure

image.png                  

 

Description

Appearance   & Physical State:

crystalline   solid

Density:

1.08   g/cm3

Melting   Point:

81-82ºC

Boiling   Point:

469.7ºC   at 760 mmHg

Refractive   Index:

1.791

Storage   Condition:

Store   in original container in a cool dark place.

Hazard   Class:

6.1(b)

Safety   Statements:

S26;   S37/39

HS   Code:

2933990090

Packing   Group:

III

RIDADR:

3249

Risk   Statements:

R36/37/38

Hazard   Codes:

Xi

 

Certificate of Analysis

 

ProductName: Anastrozole

Cas:        120511-73-1

Batch No.:    20110801

MFG Date:  Aug.01.2011

Analysis Date: Aug.04.2011

 

Inspect   Item

Quantity   Standard

Inspection   Result

Appearance

White   or off-White crystalline

powder

Conforms

Identification  

IR

Conform   with standard IR

HPLC

Conforms

Assay(on   dry basis)

98~102%

99.81%

Solubility  

Freely   soluble in methanol,

ethanol,ethylacetate   and

chloroform,slightly   soluble in

water   and 0.1M   hydrochloric

acid   solution

Conforms  

Related   substances

Impurity   B

Impurity   C

Impurity   D

Impurity   E

Single   unknown impurity

Total   unknown impurity

Total   Impurity

 

MNT0.2%

NMT0.2%

NMT0.1%

NMT0.1%

NMT0.1%

NMT0.2%

NMT0.5%

 

0.05%

0.05%

0.03%

0.03%

0.05%

0.09%

0.30%

Residual   solvents

Dichloromethane

Chloroform

Ethanol

Cyclohhexane

ethylacetate

 

MNT0.06%

NMT0.006%

NMT0.5%

NMT0.08%

NMT0.5%

 

ND

ND

0.05%

0.02%

0.1%

Residue   on ignition

NMT   0.1%

Conforms

Water  

NMT   0.3%

0.10%

Heavy   metals

NMT0.001%

<0.001%

Conclusion  

THE   RESULTS CONFORM WITH USP33 STANDARD.


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