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Acyclovir CAS No.:59277-89-3 supplier Hangzhou Shitai Biotech Co.,Ltd
Apr 25, 2018

Aciclovir (ACV), also known as acyclovir, is an antiviral medication. It is primarily used for the treatment of herpes simplex virus infections, chickenpox, and shingles. Other uses include prevention of cytomegalovirus infections following transplant and infections due to Epstein-Barr virus. It is available by mouth and intravenously.
Common side effects include nausea and diarrhea. Potentially serious side effects include kidney problems and low platelets. Greater care is recommended in those with poor liver or kidney function. It is generally considered safe for use in pregnancy with no harm having been observed. It appears to be safe during breastfeeding. Aciclovir is a nucleic acid analogue made from guanosine. It works by decreasing the production of the virus's DNA.
The discovery of aciclovir was announced in 1977. It is on the World Health Organization's List of Essential Medicines, the most important medications needed in a basic health system. It is available as a generic medication and is marketed under many brand names worldwide. The wholesale cost as of 2014 to 2016 was between US$0.03 and US$0.12 for a typical dose by mouth. The cost of a typical course of treatment in the United States is less than US$25.


PRODUCT   NAME

Acyclovir

CAS   No.:

59277-89-3

Synonyms:

acycloguanosine;

Poviral;

Formula:

C8H11N5O3

Molecular   Weight:

225.20500

PSA:

119.05000

LogP:

-0.75060

 

Structure

image.png                  

 

Description

Appearance   & Physical State:

White   to light yellow crystal powder

Density:

1.77

Melting   Point:

256-257ºC

Boiling   Point:

595ºC   at 760 mmHg

Stability:

Stable.   Incompatible with strong oxidizing agents.

Storage   Condition:

-20ºC

RTECS:

UP0791400

Safety   Statements:

S22-S24/25-S36-S26

HS   Code:

2933790090

WGK   Germany:

2

Risk   Statements:

R36/37/38

Hazard   Codes:

Xi

 

Certificate of Analysis

 

ProductName: Acyclovir

Cas:        59277-89-3

Batch No.:     130627

MFG Date:  June .27.2013

Analysis Date: June . 27.2013

 

Inspect   Item

Quantity   Standard   

Inspection   Result

Appearance

White   or almost white crystalline powder

Conforms  

Assay

(Anhydrous   basis)

98.5~101.0%

99.3%

Identification

Infrared   absorption should conform

Conforms

HPLC   retention time should

conform

Solubility  

Slight   soluble in water, freely soluble in dimethyl sulphoxide, very slightly   soluble in ethanol (96%).It dissolves in dilute solutions of mineral acids   and alkali bydroxide.

Conforms  

Water

≤6.0%

3.9%

Appearance   of solution

Clear,   not more intense than Y7

Conforms

Sulphated   Ash

≤0.1%

0.02%

Heavy   metals

≤10ppm

<10ppm

Related

substance

TLC

≤0.5%

Conforms

HPLC

Guanine:  ≤0.7%

0.5%

Single   impurity: ≤0.5%

0.3%

Total   impurities: ≤1.0%

0.3%

Particle   size

<24   microns:  ≥99%

Conforms

<12microns:   ≥90%

Conclusion  

In   accordance with USP35/BP2010.


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