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Sapacitabine

Structure : Description : Sapacitabine is a drug undergoing research for potential use in chemotherapy. Sapacitabine is an oral nucleoside analog prodrug that acts through a dual mechanism. The compound interferes with DNA synthesis by causing single-strand DNA breaks and induces arrest of the...

  • Features & Specification

    PRODUCT NAME

    Sapacitabine

    CAS No.:

    151823-14-2

    Synonyms

    N-[1-[(2R,3S,4S,5R)-3-Cyano-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-2-oxopyrimidin-4-yl]hexadecanamide

    CS-682

    Formula

    C26H42N4O5

    Molecular Weight

    490.63500

    PSA:

    137.47000

    LogP:

    4.12648

    Structure

    图片9.png 
     
    Description
    Sapacitabine is a drug undergoing research for potential use in chemotherapy.
    Sapacitabine is an oral nucleoside analog prodrug that acts through a dual mechanism. The compound interferes with DNA synthesis by causing single-strand DNA breaks and induces arrest of the cell division cycle at G2 phase.
    Both sapacitabine and its major metabolite, CNDAC, have demonstrated potent anti-tumor activity in both blood and solid tumors in preclinical studies. In a liver metastatic mouse model, sapacitabine was shown to be superior to gemcitabine (Gemzar; Lilly) or 5-FU, two widely used nucleoside analogs, in delaying the onset and growth of liver metastasis.

    Density:             1.21g/cm3
    Refractive Index       1.574
    Purity:               98%

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