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Mosapride

Structure : Description : Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist. The major active metabolite of mosapride, known as M1, additionally acts as a 5HT3 antagonist. which accelerates gastric emptying throughout the whole of the gastrointestinal tract in humans,...

  • Features & Specification

    PRODUCT NAME

    Mosapride

    CAS No.:

    112885-41-3

    Synonyms

    4-amino-5-chloro-2-ethoxy-N-[[4-[(4-fluorophenyl)methyl]morpholin-2-yl]methyl]benzamide

    Formula

    C21H25ClFN3O3

    Molecular Weight

    421.89300

    PSA:

    76.82000

    LogP:

    4.00080

    Structure
    图片12.png  

    Description
    Mosapride is a gastroprokinetic agent that acts as a selective 5HT4 agonist. The major active metabolite of mosapride, known as M1, additionally acts as a 5HT3 antagonist. which accelerates gastric emptying throughout the whole of the gastrointestinal tract in humans, and is used for the treatment of gastritis, gastroesophageal reflux disease, functional dyspepsia and irritable bowel syndrome. It is recommended to be taken on an empty stomach (i.e. at least one hour before food or two hours after food).
       
    In addition to its prokinetic properties, mosapride also exerts anti-inflammatory effects on the gastrointestinal tract which may contribute to some of its therapeutic effects. Mosapride also promotes neurogenesis in the gastrointestinal tract which may prove useful in certain bowel disorders. The neurogenesis is due to mosapride's effect on the 5-HT4 receptor where it acts as an agonist.
       
    Its common side effects include dry mouth, abdominal pain, dizziness, headache, insomnia, malaise, nausea, diarrhea and sometimes constipation. Unlike some other prokinetic agents, mosapride has little effect on potassium channels, no effect on hERG transfected cells, and no effect on cardiovascular function that could be detected in tests on humans. Due to the pharmacokinetics of mosapride, it would take 1,000–3,000 times the therapeutic dose to elicit cardiovascular effects.

    Appearance & Physical State:

    White to Off-White Crystalline Solid

    Density:

    1.272 g/cm3

    Melting Point:

    151-153ºC

    Boiling Point:

    549.2ºC at 760 mmHg

    Flash Point:

    286ºC

    Refractive Index:

    1.584

    Vapor Pressure:

    4.11E-12mmHg at 25°C

    RTECS:

    LW9100000

    Hazard Class:

    8

    Safety Statements:

    S26; S27; S28

    HS Code:

    2934999090

    Packing Group:

    II

    WGK Germany:

    3

    RIDADR:

    UN 3260 8/PG 2

    Risk Statements:

    R14; R34; R51/53; R12

    Hazard Codes:

    C; N; F+

    certificate of analysis

    ProductName: Mosapride
    Cas:        112885-41-3
    Batch No.:  20100628
    MFG Date:  June. 28.2010
    Analysis Date: June. 28.2010

    Inspect Item

    Quantity Standard

    Inspection Result

    Appearance

    White or almost white crystalline
         powder

    Almost white crystalline
         powder

    Melting point

    153.0℃~157.0℃

    155.0℃~156.5℃

    Color of solution(DMF)

    Light yellow or light brown,no
         insoluble substance

    Conforms

    Heavy metals

    15ppm

    <15ppm

    Residue on ignition

    0.1%

    0.06%

    Loss on drying

    0.5%

    0.12%

    Purity(HPLC)

    99.5%

    99.81%

    Conclusion

    In accordance with enterprise standard

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