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Daptomycin

Structure : Description Certificate of Analysis ProductName: Daptomycin Cas: 103060-53-3 Batch No.: 20120201 MFG Date: Feb.01.2012 Analysis Date: Feb.01.2012

  • Features & Specification

    PRODUCT   NAME

    Daptomycin

    CAS   No.:

    103060-53-3

    Synonyms:

    CUBICIN DAPTOMYCIN;

    N-(1-Oxodecyl)-L-tryptophyl-D-asparaginyl-L-α-aspartyl-L-threonylglycyl-L-ornithinyl-L-α-aspartyl-D-alanyl-L-α-aspartylglycyl-D-seryl-(3R)-3-methyl-L-α-glutamyl-α,2-diamino-γ-oxo-benzenebutanoicacid(13-4)lactone;

    Formula:

    C72H101N17O26

    Molecular   Weight:

    1620.67000

    PSA:

    702.02000

    LogP:

    0.88280

     

    Structure

    image.png                         

     

    Description

    Appearance   & Physical State:

    White   powder

    Density:

    1.45   g/cm3

    Boiling   Point:

    2078.2ºC   at 760 mmHg

    Flash   Point:

    1210.7ºC

    Refractive   Index:

    1.638

    Vapor   Pressure:

    0mmHg   at 25°C

     

    Certificate of Analysis

     

    ProductName: Daptomycin

    Cas:        103060-53-3

    Batch No.:     20120201

    MFG Date:  Feb.01.2012

    Analysis Date: Feb.01.2012

     

    Inspect   Item

    Quantity   Standard

    Inspection   Result

    Appearance  

    Yellow   or pale yellow amorphous powder

    Conforms

    Identification  

    HPLC,   IR, UV

    Conforms

    Specific   Rotation

    +17°~+25°

    +21.6°

    PH

    4.0~5.0

    4.78

    Residue   on ignition

    ≤4.0%

    3.27%

    Related   Substances(HPLC)

    Anhydro-datomycin≤2.5%

    0.48%

    β-Isomer≤2.0%

    0.55%

    Lactone   hydrolysis product≤1.0%

    0.42%

    Any   other impurity≤1.0%

    <1.0%

    Total   impurities≤4.0%

    3.08%

    Residual   Organic

    Solven

    Ethanol≤1.0%

    Absent

    Isopropanol≤0.5%

    Absent

    Heavy   Metals

    ≤20PPM

    <20PPM

    Water

    ≤10.0%

    2.86%

    Assay(on   the anhydrous basis)

    ≥93.0%

    99.3%

    Bacterial   Endotoxin

    <1.25EU/MG

    <0.1EU/MG

    Conclusion  

    In   accordance with enterprise standard


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