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Cobimetinib

Structure : Description : Cobimetinib (trade name Cotellic) is a MEK inhibitor developed by Exelixis and Genentech. It is used in combination with vemurafenib, a BRAF inhibitor, to treat melanoma. In November 2015, the U.S. Food and Drug Administration approved cobimetinib for unresectable or...

  • Features & Specification

    PRODUCT NAME

    Cobimetinib

    CAS No.:

    934660-93-2

    Synonyms

    [3,4-Difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-(2S)-2-piperidinyl-1-azetidinyl]methanone

    GDC 0973;XL 518;

    Formula:

    C21H21F3IN3O2

    Molecular Weight:

    531.31000

    PSA:

    64.60000

    LogP:

    4.12080

    Structure
      图片5.png

    Description: 

    Cobimetinib (trade name Cotellic) is a MEK inhibitor developed by Exelixis and Genentech. It is used in combination with vemurafenib, a BRAF inhibitor, to treat melanoma. In November 2015, the U.S. Food and Drug Administration approved cobimetinib for unresectable or metastatic melanoma with a BRAF V600E or V600K mutation, in combination with vemurafenib (Zelboraf). Cobimetinib is not indicated for treatment of patients with wild-type BRAF melanoma.
    Cobimetinib in combination with vemurafenib is reportedly priced at $17,600 per month, or about $211,000 per year. A competing dual therapy, using dabrafenib along with trametinib, is also approved by the FDA, and is reported to cost $15,300 monthly, or $183,600 per year.
    We can provide this product with purity 99%.


    The test result of COA

    ProductName: Cobimetinib

    Cas:       934660-93-2

    Batch No.:    20171012

    MFG Date:  Oct.12.2017

    Analysis Date:Oct.12.2017

     

     

     

    Inspect Item

    Quantity Standard

    Inspection Result

    Appearance

    White to light   yellow powder

    White powder

    Identification

    Positive

    Conforms

    Purity

    98%

    99.40%

    Single impurity

    0.20%

    0.33%

    Residual solvent

    0.50%

    0.30%

    EE value

    99%

    99.82%

    Conclusion

    In accordance with enterprise standard


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