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Acyclovir

Structure : Description Certificate of Analysis ProductName: Acyclovir Cas: 59277-89-3 Batch No.: 130627 MFG Date: June .27.2013 Analysis Date: June . 27.2013

  • Features & Specification

    PRODUCT   NAME

    Acyclovir

    CAS   No.:

    59277-89-3

    Synonyms:

    acycloguanosine;

    Poviral;

    Formula:

    C8H11N5O3

    Molecular   Weight:

    225.20500

    PSA:

    119.05000

    LogP:

    -0.75060

     

    Structure

    image.png                  

     

    Description

    Appearance   & Physical State:

    White   to light yellow crystal powder

    Density:

    1.77

    Melting   Point:

    256-257ºC

    Boiling   Point:

    595ºC   at 760 mmHg

    Stability:

    Stable.   Incompatible with strong oxidizing agents.

    Storage   Condition:

    -20ºC

    RTECS:

    UP0791400

    Safety   Statements:

    S22-S24/25-S36-S26

    HS   Code:

    2933790090

    WGK   Germany:

    2

    Risk   Statements:

    R36/37/38

    Hazard   Codes:

    Xi

     

    Certificate of Analysis

     

    ProductName: Acyclovir

    Cas:        59277-89-3

    Batch No.:     130627

    MFG Date:  June .27.2013

    Analysis Date: June . 27.2013

     

    Inspect   Item

    Quantity   Standard   

    Inspection   Result

    Appearance

    White   or almost white crystalline powder

    Conforms  

    Assay

    (Anhydrous   basis)

    98.5~101.0%

    99.3%

    Identification

    Infrared   absorption should conform

    Conforms

    HPLC   retention time should

    conform

    Solubility  

    Slight   soluble in water, freely soluble in dimethyl sulphoxide, very slightly   soluble in ethanol (96%).It dissolves in dilute solutions of mineral acids   and alkali bydroxide.

    Conforms  

    Water

    ≤6.0%

    3.9%

    Appearance   of solution

    Clear,   not more intense than Y7

    Conforms

    Sulphated   Ash

    ≤0.1%

    0.02%

    Heavy   metals

    ≤10ppm

    <10ppm

    Related

    substance

    TLC

    ≤0.5%

    Conforms

    HPLC

    Guanine:  ≤0.7%

    0.5%

    Single   impurity: ≤0.5%

    0.3%

    Total   impurities: ≤1.0%

    0.3%

    Particle   size

    <24   microns:  ≥99%

    Conforms

    <12microns:   ≥90%

    Conclusion  

    In   accordance with USP35/BP2010.


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